![]() ![]() REM sleep behavior disorder responds well to low doses of clonazepam. Bruxism also responds to clonazepam in the short term. Restless legs syndrome can be treated using clonazepam as a third-line treatment option, as the use of clonazepam is still investigational. Clonazepam is also effective in the management of acute mania. Some long-term trials have suggested a benefit of clonazepam for up to three years without the development of tolerance, but these trials were not placebo-controlled. The effectiveness of clonazepam in the short-term treatment of panic disorder has been demonstrated in controlled clinical trials.
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